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Buy Nitrofurantoin 100mg 50mg online over the counter
Shelf life: until 12.2023
Manufacturer: Martin & Harris / Ranbaxy
Active Ingredient: Nitrofurantoin
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What is Nitrofurantoin?
A broad spectrum antimicrobial drug, a derivative of nitrofuran. It has a bacteriostatic and bactericidal effect in urinary tract infections. Nitrofurantoin is active against Esherichia coli, Klebsiella spp., Enterobacter spp., Proteus spp.
Effective mainly with urinary tract infections.
It is well absorbed from the digestive tract. Bioavailability is 50% (food increases bioavailability). The absorption rate depends on the size of the crystals (the microcrystalline form is characterized by rapid solubility and absorption rate, short time to reach Cmax in the urine). Binding to plasma proteins — 60%. Metabolized in the liver and muscle tissue. T1 / 2 — 20-25 min. Penetrates through the BBB, the placental barrier, excreted in breast milk. It is excreted completely by the kidneys (30-50% — unchanged).
Indications for use
Infectious and inflammatory diseases of the urinary tract (including pyelonephritis, cystitis) caused by microorganisms sensitive to nitrofurantoin.
Contraindications
- Severe renal excretory function
- Renal failure
- Oliguria
- Glucose-6-phosphate dehydrogenase deficiency
- Pregnancy
- Early childhood (up to 1 month)
- Hypersensitivity to nitrofurantoin
- Heart failure stage II-III
- Cirrhosis of the liver
- Chronic hepatitis
- Acute porphyria
- Lactation
Instruction for use
For adults: The dose for adults is 50-100 mg, the frequency of use is 4 times / day. The daily dose for children is 5-7 mg / kg in 4 divided doses. The duration of treatment is 7 days. If necessary, it is possible to continue treatment for another 3 days (only after urine is checked for sterility). With long-term maintenance treatment, the dose of nitrofurantoin should be reduced.
Side effects
- From the respiratory system: chest pain, cough, shortness of breath, pulmonary infiltrates, eosinophilia, interstitial pneumonitis or fibrosis, decreased respiratory function, an attack of bronchial asthma in patients with a history of asthma.
- From the digestive system: discomfort in the epigastrium, anorexia, nausea, vomiting; rarely — hepatitis, cholestatic jaundice, abdominal pain, diarrhea.
- From the side of the central nervous system and peripheral nervous system: peripheral neuropathy, headache, nystagmus, dizziness, drowsiness.
- From the hemopoietic system: leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, megaloblastic anemia (these changes are reversible).
- Allergic reactions: urticaria, Quincke’s edema, pruritus, rash; very rarely — anaphylactic shock.
- Dermatological reactions: exfoliative dermatitis, erythema multiforme.
- Other: drug fever, arthralgia, flu-like symptoms are possible, urinary tract superinfection, often caused by Pseudomonas aeruginosa.